Clement Clarke International has been a major force in the manufacturing of innovative medical instrumentation worldwide and is striving to improve patient inhaler technique. This project was designed to undertake in vitro testing of devices developed to improve patient use of pMDIs. Studies were focused a universal training aid, Flo-Tone, a universal audible training aid / spacer device, Flo-Tone CR and a valved holding chamber, Able Spacer. Data from these studies have been reported at a number of scientific meetings e.g.